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A. Process Analytical Techniques B. Process Monitoring (on-line, in-line, non-invasive) C. Multivariate Data Analysis D. Process Modelling E. Process Control

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B1 Reaction monitoring B2 Monitoring of drying and powder blending B3 Biological process analysis B4 Microreactors and flow chemistry

title year authors journal volume pages Categories Actions
A heuristic approach to handling missing data in biologics manufacturing databases 2019 Mante, J., Gangadharan, N., Sewell, D. J., Turner, R., Field, R., Oliver, S. G., . . . Dikicioglu, D. Bioprocesses and Biosystems Engineering 42 (4) 657-663 B3 Biological process analysis, D3 Performance monitoring DOI
A Mechanistic and Cautionary Case Study on the Use of Alternating Potential in Electrochemical Reactions 2020 Wills Alfie G., Poole Darren L., Alder Catherine M., Reid Marc ChemElectroChem 7 2771-2776 B1 Reaction monitoring, D1 Kinetic modelling DOI
A Mechanistic and Cautionary Case Study on the Use of Alternating Potential in Electrochemical Reactions 2020 Wills Alfie G., Poole Darren L., Alder Catherine M., Reid Marc ChemElectroChem 7 2771-2776 B2 Monitoring of drying and powder blending DOI
A micro reactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme 2009 Hickey AM, Ngamsom B, Wiles C, Greenway GM, Watts P and Littlechild JA 4(4) 510-516 B3 Biological process analysis, B4 Microreactors and flow chemistry DOI
Biofluid analysis and classification using IR and 2D-IR spectroscopy 2021 Rutherford Samantha H., Nordon Alison, Hunt Neil T., Baker Matthew J. Chemometrics and Intelligent Laboratory Systems 217 104408 B3 Biological process analysis DOI
Biomass composition: the “elephant in the room” of metabolic modelling 2015 Dikicioglu Duygu, Kirdar Betul, Oliver Stephen G. Metabolomics 11 1690-1701 B3 Biological process analysis, D2 Multi-block, predictive and multi-scale modelling methods DOI
CamOptimus: a tool for exploiting complex adaptive evolution to optimize experiments and processes in biotechnology 2017 Cankorur-Cetinkaya Ayca, Dias Joao M. L., Kludas Jana, Slater Nigel K. H., Rousu Juho, Oliver Stephen G., Dikicioglu Duygu Microbiology 163 829-839 B3 Biological process analysis, D3 Performance monitoring DOI
CLUSTERnGO: a user-defined modelling platform for two-stage clustering of time-series data 2016 Fidaner Isik Baris, Cankorur-Cetinkaya Ayca, Dikicioglu Duygu, Kirdar Betul, Cemgil Ali Taylan, Oliver Stephen G. Bioinformatics 32 388-397 C1 Multivariate data analysis, B3 Biological process analysis DOI
Combined shifted-excitation Raman difference spectroscopy and support vector regression for monitoring the algal production of complex polysaccarides 2013 Noack K, Eskofier B, Kiefer J, Dilk C, Bilow G, Schirmer M, Buchholz R, Leipertz A Analyst 138 5639-5646 B3 Biological process analysis DOI
Combining model structure identification and hybrid modelling for photo-production process predictive simulation and optimisation 2020 Zhang Dongda, Savage Thomas R., Cho Bovinille A. Biotechnology and Bioengineering 117 3356-3367 B3 Biological process analysis DOI
Comparison of physics-based and data-driven modelling techniques for dynamic optimisation of fed-batch bioprocesses 2019 Del Rio-Chanona Ehecatl Antonio, Ahmed Nur Rashid, Wagner Jonathan, Lu Yinghua, Zhang Dongda, Jing Keju Biotechnology and Bioengineering 116 2971-2982 B3 Biological process analysis DOI
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena 2022 Barrington Henry, Dickinson Alan, McGuire Jake, Yan Chunhui, Reid Marc Organic Process Research & Development 26 3073-3088 B2 Monitoring of drying and powder blending DOI
Computer vision for non-contact monitoring of catalyst degradation and product formation kinetics 2023 Yan Chunhui, Cowie Megan, Howcutt Calum, Wheelhouse Katherine M. P., Hodnett Neil S., Kollie Martin, Gildea Martin, Goodfellow Martin H., Reid Marc Chemical Science 14 5323-5331 B2 Monitoring of drying and powder blending DOI
Consideration of some sampling problems in the on-line analysis of batch processes by low-field NMR spectrometry 2008 Nordon A, Diez-Lazaro A, Wong CWL, McGill CA, Littlejohn D, Weerasinghe M, Mamman DA, Hitchman ML and Wilkie J Analyst 133 339-347 B1 Reaction monitoring, A6. Low field NMR spectrometry DOI
Considerations for the selection and design of sampling systems for heterogeneous processes in a stirred tank reactor 2005 Diez-Lazaro A, Hitchman M L and Littlejohn D Chemical Engineering Research and Design 83 344-351 B1 Reaction monitoring DOI
Continuous flow organic synthesis, a tool for the modern medicinal chemistry 2009 Wiles C and Watts P Fut. Med. Chem. 1593-1612 B4 Microreactors and flow chemistry DOI
Determination of Aniline in Hydrofluoric Acid solutions by NIR Spectrometry with a Fibre-optic Interface 1998 McDonald J, McIntyre A, Hitchman M L, Littlejohn D Applied Spectroscopy 52 908-911 B1 Reaction monitoring DOI
Development of a gas-phase Raman instrument using a hollow core anti-resonant tubular fibre 2021 Brooks William S.M., Partridge Matthew, Davidson Ian A.K., Warren Charles, Rushton George, Large Joseph, Wharton Michael, Storey Jonathan, Wheeler Natalie V., Foster Michael J. Journal of Raman Spectroscopy 52 1772-1782 B2 Monitoring of drying and powder blending, B3 Biological process analysis, B4 Microreactors and flow chemistry, B1 Reaction monitoring, A1. Non-invasive Raman spectrometry, A5. ATR-MIR spectrometry DOI
Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme 2010 Ngamsom B, Hickey AM, Greenway GM, Littlechild JA, Watts P and Wiles C J. Mol. Catal. B Enzym. 63 81-86 B3 Biological process analysis, B4 Microreactors and flow chemistry DOI
Development of a spatially offset Raman spectroscopy probe for monitoring pharmaceutical drying 2023 Al-Attili Mais, Ferreira Carla, Price Chris, Faulds Karen, Chen Yi-Chieh Chemical Engineering Research and Design 192 510-520 B2 Monitoring of drying and powder blending, A1. Non-invasive Raman spectrometry, C1 Multivariate data analysis DOI
Dynamic modeling and optimization of sustainable algal production with uncertainty using multivariate Gaussian processes 2018 Bradford Eric, Schweidtmann Artur M., Zhang Dongda, Jing Keju, del Rio-Chanona Ehecatl Antonio Computers & Chemical Engineering 118 143-158 B3 Biological process analysis DOI
Dynamic modelling of the killing mechanism of action by virus-infected yeasts 2019 Sheppard Sean, Dikicioglu Duygu Journal of The Royal Society Interface 16 20190064 B3 Biological process analysis, D1 Kinetic modelling DOI
Dynamic Proteomic Profiling of Extra-Embryonic Endoderm Differentiation in Mouse Embryonic Stem Cells 2015 Mulvey Claire M., Schröter Christian, Gatto Laurent, Dikicioglu Duygu, Fidaner Isik Baris, Christoforou Andy, Deery Michael J., Cho Lily T. Y., Niakan Kathy K., Martinez-Arias Alfonso, Lilley Kathryn S. STEM CELLS 33 2712-2725 C1 Multivariate data analysis, B3 Biological process analysis DOI
Effects of particle size and cohesive properties on mixing studied by non-contact NIR 2008 Bellamy LJ, Nordon A and Littlejohn D Int. J. Pharm 361 87-91 A2 Particle size effects in Raman and NIR, B2 Monitoring of drying and powder blending DOI
Enhanced Chemical Synthesis in Flow Reactors 2009 Wiles C and Watts P Chemica Oggi 27(3) 34-36 B4 Microreactors and flow chemistry
Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements 2019 Dikicioglu Duygu, Oliver Stephen G. Biotechnology and Bioengineering 116 610-621 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Extracellular acidity and oxygen availability conjointly control eukaryotic cell growth via modulation of cytoplasmic translation. 2019 Dikicioglu, D Turkish Journal of Biochemistry B3 Biological process analysis, C1 Multivariate data analysis DOI
Factors affecting broadband acoustic emission measurements of a heterogeneous reaction 2006 Nordon A, Carella Y, Gachagan A, Littlejohn D and Hayward G Analyst 131 323-330 B1 Reaction monitoring, A7. Ultrasonics and acoustic emission spectrometry DOI
Fermentation process tracking through enhanced spectral calibration modeling 2007 Triadaphillou S, Martin E, Montague G, Nordon A, Jeffkins P and Stimpson S Biotechnol. Bioeng. 97 554-567 B3 Biological process analysis, C2 Calibration transfer/model maintenance DOI
Flux Balance Analysis of a Genome-Scale Yeast Model Constrained by Exometabolomic Data Allows Metabolic System Identification of Genetically Different Strains 2007 Cakir T., Efe C., Dikicioglu D., Hortacsu A., Kirdar B., Oliver S.G. Biotechnology Progress 23 320-326 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Formal model of Parkinson’s disease neurons unveils possible causality links in the pathophysiology of the disease 2020 Nadal Morgane, Schierle Gabriele S. Kaminski, Dikicioglu Duygu D1 Kinetic modelling, B3 Biological process analysis DOI
Handling variability and incompleteness of biological data by flexible nets: a case study for Wilson disease 2018 Júlvez Jorge, Dikicioglu Duygu, Oliver Stephen G. npj Systems Biology and Applications 4 B3 Biological process analysis, D1 Kinetic modelling DOI
How yeast re-programmes its transcriptional profile in response to different nutrient impulses 2011 Dikicioglu Duygu, Karabekmez Erkan, Rash Bharat, Pir Pinar, Kirdar Betul, Oliver Stephen G BMC Systems Biology 5 148 C1 Multivariate data analysis, B3 Biological process analysis DOI
Hybrid physics-based and data-driven modeling for bioprocess online simulation and optimization 2019 Zhang Dongda, Del Rio-Chanona Ehecatl Antonio, Petsagkourakis Panagiotis, Wagner Jonathan Biotechnology and Bioengineering 116 2919-2930 B3 Biological process analysis DOI
Improved method for kinetic studies in microreactors using flow manipulation and non-invasive Raman spectrometry 2011 Mozharov S, Nordon A, Littlejohn D, Wiles C, Watts P, Dallin P and Girkin JM Journal of the American Chemical Society 133 3601-3608 A1. Non-invasive Raman spectrometry, B1 Reaction monitoring, B4 Microreactors and flow chemistry, D1 Kinetic modelling DOI
Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions 2019 Lularevic M, Racher AJ, Jaques C, Kiparissides A Biotechnology and BioEngineering 116 2339-2352 B3 Biological process analysis DOI
In situ monitoring of powder blending by non-invasive Raman spectrometry with wide area illumination 2013 Allan P, Bellamy L, Nordon A, Littlejohn D, Andrews J and Dallin P Journal of Pharmaceutical and Biomedical Analysis 76 28 - 35 A1. Non-invasive Raman spectrometry, B2 Monitoring of drying and powder blending DOI
In situ monitoring of the seed stage of a fermentation process using non-invasive NIR spectrometry 2008 Nordon A, Littlejohn D, Dann AS, Jeffkins PA, Richardson MD and Stimpson SL Analyst 5 660-666 B3 Biological process analysis DOI
In-line monitoring of esterification using a miniaturised mid-infrared spectrometer 2003 McGill C A, Ferguson R H, Donoghue K, Nordon A and Littlejohn D Analyst 128 1467-1470 B1 Reaction monitoring, A5. ATR-MIR spectrometry DOI
Integration of Metabolic Modeling and Phenotypic Data in Evaluation and Improvement of Ethanol Production Using Respiration-Deficient Mutants of Saccharomyces cerevisiae 2008 Dikicioglu Duygu, Pir Pinar, Onsan Z. Ilsen, Ulgen Kutlu O., Kirdar Betul, Oliver Stephen G. Applied and Environmental Microbiology 74 5809-5816 C1 Multivariate data analysis, B3 Biological process analysis DOI
Integration of Metabolic Modeling and Phenotypic Data in Evaluation and Improvement of Ethanol Production Using Respiration-Deficient Mutants of Saccharomyces cerevisiae 2008 Dikicioglu Duygu, Pir Pinar, Onsan Z. Ilsen, Ulgen Kutlu O., Kirdar Betul, Oliver Stephen G. Applied and Environmental Microbiology 74 5809-5816 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Investigating the feasibility of mid infrared spectroscopy for monitoring an industrial de-racemization biotransformation process 2012 Gardner P, Arnold SA, Brown F, Carr R, Nordon A, Harvey LM and McNeil B. Analytica Chimica Acta, 779 50-55 B3 Biological process analysis, A5. ATR-MIR spectrometry DOI
Investigation of factors affecting isolation of needle-shaped particles in a vacuum agitated filter drier through non-invasive measurements by Raman spectometry 2013 Hamilton P, Littlejohn D, Nordon A, Sefcik J, Slavin P, J Andrews and Dallin P Chemical Engineering Science 101 878-885 A1. Non-invasive Raman spectrometry, B2 Monitoring of drying and powder blending DOI
Kinetic and hybrid modeling for yeast astaxanthin production under uncertainty 2021 Vega-Ramon Fernando, Zhu Xianfeng, Savage Thomas R., Petsagkourakis Panagiotis, Jing Keju, Zhang Dongda Biotechnology and Bioengineering 118 4854-4866 B1 Reaction monitoring, D1 Kinetic modelling DOI
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and gene therapy manufacturing 2023 Williams Thomas, Kalinka Kevin, Sanches Rui, Blanchard-Emmerson Greg, Watts Samuel, Davies Lee, Knevelman Carol, McCloskey Laura, Jones Peter, Mitrophanous Kyriacos, Miskin James, Dikicioglu Duygu Scientific Reports 13 B2 Monitoring of drying and powder blending, D2 Multi-block, predictive and multi-scale modelling methods DOI
Metabolic modeling to identify engineering targets forKomagataella phaffii: The effect of biomass composition on gene target identification 2017 Cankorur-Cetinkaya Ayca, Dikicioglu Duygu, Oliver Stephen G. Biotechnology and Bioengineering 114 2605-2615 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene 2019 Dikicioglu Duygu, Coxon James W. M. T., Oliver Stephen G. Molecular Omics 15 340-347 B3 Biological process analysis, C1 Multivariate data analysis DOI
Microreactors as tools for high-throughput synthesis 2009 Wiles C and Watts P Speciality Chem. Magazine 40-41 B4 Microreactors and flow chemistry
Monitoring of a heterogeneous reaction by acoustic emission 2004 Nordon A, Waddell R J H, Bellamy L J, Gachagan A, McNab D, Littlejohn D and Hayward G Analyst 129 463-467 B1 Reaction monitoring, A7. Ultrasonics and acoustic emission spectrometry DOI
Monitoring of an esterification reaction by on-line direct liquid sampling mass spectrometry and in-line mid infrared spectrometry with an attenuated total reflectance probe 2014 Owen A W, McAulay E A J, Nordon A, Littlejohn D, Lynch T P, Lancaster S J, Wright R G Analytica Chimica Acta, 14.08.2014 B1 Reaction monitoring, A5. ATR-MIR spectrometry, A8. Process mass spectrometry DOI
Multi-scale Multiblock Batch Monitoring:Sensor and Process Drift and Degradation 2015 Alawi A, Zhang J and Morris J, Org. Process Res. Dev. 19 (1) 145-157 B1 Reaction monitoring, D2 Multi-block, predictive and multi-scale modelling methods DOI
Multivariate kinetic hard-modelling of spectroscopic data: A comparison of the esterification of butanol by acetic anhydride on different scales and with different instruments 2008 Puxty, Neuhold Y-M, Ehly M, Gemperline PJ, Nordon A, Littlejohn D, Basford JK, De Cecco M and Hunderbuhler K Chem. Eng. Sci., 63 (19) 4800-4809 B1 Reaction monitoring, D1 Kinetic modelling DOI
Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe 2010 Mozharov S, Nordon A, Girkin JM and Littlejohn D Lab on a Chip 10 2101-2107 A1. Non-invasive Raman spectrometry, B1 Reaction monitoring, B4 Microreactors and flow chemistry DOI
Non-invasive monitoring of the growth of metal-organic frameworks (MOFs) <i>via</i> Raman spectroscopy 2023 Chong Magdalene, Parrott Andrew John, Ashworth David, Fletcher Ashleigh J., Nordon Alison Physical Chemistry Chemical Physics B1 Reaction monitoring, A1. Non-invasive Raman spectrometry DOI
Non-invasive monitoring of the mixing of pharmaceutical powders by broadband acoustic emission 2010 Allan P, Ballamy LJ, Nordon A and Littlejohn D Analyst 135 518-524 B2 Monitoring of drying and powder blending, A7. Ultrasonics and acoustic emission spectrometry DOI
Real-time monitoring of powder mixing in a convective blender using non-invasive reflectance NIR spectrometry 2008 Bellamy LJ, Nordon A and Littlejohn D Analyst 133 58-64 A2 Particle size effects in Raman and NIR, B2 Monitoring of drying and powder blending DOI
Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism 2018 Dikicioglu Duygu, Dereli Eke Elif, Eraslan Serpil, Oliver Stephen G., Kirdar Betul Cell Communication and Signaling 16 C1 Multivariate data analysis, B3 Biological process analysis DOI
Scale-up of batch kinetic models 2007 Ehly M, Gemperline PJ, Nordon A, Littlejohn D, Basford JK and De Cecco M Anal Chim Acta 595 80-88 B1 Reaction monitoring, D1 Kinetic modelling Download DOI
Sensing change in batch reactors 2008 Ashe R, Littlejohn D, Nordon A and Allan P Chem Eng 115 56-59 B1 Reaction monitoring
Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment 2012 Dikicioglu Duygu, Dunn Warwick B., Kell Douglas B., Kirdar Betul, Oliver Stephen G. Molecular BioSystems 8 1760 C1 Multivariate data analysis, B3 Biological process analysis DOI
Studies of particle drying using non-invasive Raman spectrometry and particle size analysis 2011 Hamilton P, Littlejohn D, Nordon A, Sefcik J, Slavin P, Dallin P and Andrews J Analyst 136 2168-2174 A1. Non-invasive Raman spectrometry, B2 Monitoring of drying and powder blending DOI
Teaching old presumptive tests new digital tricks with computer vision for forensic applications 2023 Bugeja Nathalie, Oliver Cameron, McGrath Nicole, McGuire Jake, Yan Chunhui, Carlysle-Davies Felicity, Reid Marc Digital Discovery 2 1143-1151 B2 Monitoring of drying and powder blending DOI
The development and evaluation of a continuous flow process for the lipase mediated oxidation of alkenes 2009 Wiles C, Hammond MJ and Watts P Beilstein J. Org. Chem. 5(27) 1-12 B4 Microreactors and flow chemistry DOI
The use of immobilised crown ethers as in situ N-protecting groups in organic synthesis and their application under continuous flow 2009 Wild GP, Wiles C, Watts P and Haswell SJ Tetrahedron 65 1618-1629 B4 Microreactors and flow chemistry DOI
Towards better understanding of an industrial cell factory investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris 2013 Fazenda M, Dias J, Harvey L, Nordon A, Edrada-Ebel R, Littlejohn D and NcNeil B Microbial Cell Factories 12:51 B3 Biological process analysis DOI
Trialkylammonium salt degradation: implications for methylation and cross-coupling 2021 Washington Jack B., Assante Michele, Yan Chunhui, McKinney David, Juba Vanessa, Leach Andrew G., Baillie Sharon E., Reid Marc Chemical Science 12 6949-6963 B1 Reaction monitoring, D1 Kinetic modelling DOI
Validity of particle size analysis techniques for measurement of the attrition that occurs during vacuum agitated powder drying of needle-shaped particles 2012 Hamilton P, Littlejohn D, Nordon A, Sefcik J and Slavin P Analyst 137 118 - 125 B2 Monitoring of drying and powder blending DOI
Yeast cells with impaired drug resistance accumulate glycerol and glucose 2014 Dikicioglu, D., Oc, S., Rash, B. M., Dunn, W. B., Pir, P., Kell, D. B., . . . Oliver, S. G Molecular Biosytems 10 (1) 93-102 C1 Multivariate data analysis, B3 Biological process analysis DOI